ARV-471

• Target:

  Estrogen Receptor/ERR|||PROTACs

• Related Pathways:

  Endocrinology/Hormones|||PROTAC

• Purity:

  >99.99%

• Bioactivity:

  Vepdegestrant (ARV-471) is an estrogen receptor (ER) ? PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.

• Smiles:

  OC=1C=C2C ([C@H] ([C@H] (CC2) C3=CC=CC=C3) C4=CC=C (C=C4) N5CCC (CN6CCN (CC6) C=7C=C8C (=CC7) C (=O) N (C8) [C@@H]9C (=O) NC (=O) CC9) CC5) =CC1

• Molecular Formula:

  C45H49N5O4

• Molecular Weight:

  723.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2229711-68-4