ARV-471

• CAS Number :

  2229711-68-4

• Target :

  Estrogen Receptor/ERR|||PROTACs

• Related Pathways :

  Endocrinology/Hormones|||PROTAC

• Purity :

  >99.99%

• Bioactivity :

  Vepdegestrant (ARV-471) is an estrogen receptor (ER) ? PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.

• Smiles :

  OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5)=CC1

• Molecular Formula :

  C45H49N5O4

• Molecular Weight :

  723.9

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C