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JAK1/2-IN-1

CAT: 0931-T209137-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209137-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3023876-01-6
Target
JAK, Interleukin
Related Pathways
Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Angiogenesis, Immunology/Inflammation
Bioactivity
JAK1/2-IN-1 is a potent inhibitor of JAK1 and JAK2, with IC50 values of 0.4 nM and 8.1 nM, respectively. Additionally, JAK1/2-IN-1 inhibits IL-4 and IL-13, with IC50 values of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a) .
Smiles
C(F)(F)(F)C1=C2C(=CC(NC=3N=C(N[C@@H]4[C@@H](C#N)CCOC4)C(C)=CN3)=C1)COB2O
Molecular Formula
C19H19BF3N5O3
Molecular Weight
433.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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