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JAK1-IN-17

CAT: 0931-T212341-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212341-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1315490-71-1
Target
JAK
Related Pathways
Stem Cells, JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
JAK1-IN-17 (Compound 31) is a highly selective JAK1 inhibitor with a Ki of 1.9 nM. It exhibits low whole blood migration, allowing it to maintain effective pharmacological activity in whole blood. JAK1-IN-17 is also a nitrile-containing compound that provides stable but weak reversible inhibition of CYP3A4 using a midazolam probe (IC50= 7.9 μM) . This compound is applicable in cancer research.
Smiles
[C@H](C)(O)C=1N(C2=C3C(NC=C2N1)=NC=C3)[C@@H]4CC[C@@H](C#N)CC4
Molecular Formula
C17H19N5O
Molecular Weight
309.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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