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PROTAC GPX4 degrader-2

CAT: 0931-T209085-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209085-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ferroptosis, PROTACs, Glutathione Peroxidase
Related Pathways
Metabolism, Apoptosis, PROTAC
Bioactivity
PROTACGPX4 degrader-2 (compound 18a) is a proteolysis-targeting chimera (PROTAC) that targets the degradation of glutathione peroxidase 4 (GPX4), with a DC50, 48h value of 1.68 μM. It induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. Additionally, PROTACGPX4 degrader-2 exhibits antiproliferative activity.
Molecular Formula
C50H61ClN8O9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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