KB02-SLF

• Target:

  FKBP|||PROTACs

• Related Pathways:

  PROTAC|||Autophagy|||Immunology/Inflammation|||Apoptosis

• Bioactivity:

  KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, also known as a molecular glue, that facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, thus forming KB02-SLF[1] and enhancing the longevity of protein degradation in biological systems.

• Smiles:

  O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(COC3=CC4=C(N(C(CCl)=O)CCC4)C=C3)=O)=O)=C2)CCC5=CC=C(OC)C(OC)=C5

• Molecular Formula:

  C50H65ClN4O12

• Molecular Weight:

  949.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C