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KB02-SLF

CAT: 0931-T18061-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T18061-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
FKBP, PROTACs
Related Pathways
PROTAC, Autophagy, Immunology/Inflammation, Apoptosis
Bioactivity
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, also known as a molecular glue, that facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, thus forming KB02-SLF[1] and enhancing the longevity of protein degradation in biological systems.
Smiles
O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCOCCOCCNC(COC3=CC4=C(N(C(CCl)=O)CCC4)C=C3)=O)=O)=C2)CCC5=CC=C(OC)C(OC)=C5
Molecular Formula
C50H65ClN4O12
Molecular Weight
949.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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