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PHD2-IN-4

CAT: 0931-T205562-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T205562-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2924181-60-0
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolism, Chromatin/Epigenetic
Bioactivity
PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.
Smiles
N#CC1=CC=C(C=C1)CNC(=O)C2=NC=C3N=C(C=CC3=C2O)N4CCOCC4
Molecular Formula
C21H19N5O3
Molecular Weight
389.407
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-[(4-cyanophenyl)methyl]-5-hydroxy-2-morpholin-4-yl-1,7-naphthyridine-6-carboxamide
CAS Number2924181-60-0
PubChem CID168817517
IUPAC NameN-[(4-cyanophenyl)methyl]-5-hydroxy-2-morpholin-4-yl-1,7-naphthyridine-6-carboxamide
Molecular FormulaC21H19N5O3
Molecular Weight389.4
XLogP2.2
Topological Polar Surface Area111
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity609
SMILES
C1COCCN1C2=NC3=CN=C(C(=C3C=C2)O)C(=O)NCC4=CC=C(C=C4)C#N
InChI
InChI=1S/C21H19N5O3/c22-11-14-1-3-15(4-2-14)12-24-21(28)19-20(27)16-5-6-18(25-17(16)13-23-19)26-7-9-29-10-8-26/h1-6,13,27H,7-10,12H2,(H,24,28)
InChIKey
LFPWGXGGSSZTIU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[(4-cyanophenyl)methyl]-5-hydroxy-2-morpholin-4-yl-1,7-naphthyridine-6-carboxamide
CAS: 2924181-60-0
CID: 168817517
Formula: C21H19N5O3
MW: 389.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight389.4
XLogP32.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass389.14878949
Monoisotopic Mass389.14878949
Topological Polar Surface Area111 Ų
Heavy Atom Count29
Formal Charge0
Complexity609
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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