BRD4 degrader-5

• Target:

  Autophagy|||AUTACs|||Epigenetic Reader Domain

• Related Pathways:

  PROTAC|||Chromatin/Epigenetic|||Autophagy

• Bioactivity:

  BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 ?M) . It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 ?M.

• Molecular Formula:

  C35H42ClN7O2S

• Molecular Weight:

  660.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C