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HDAC6 degrader-1

CAT: 0931-T77922-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T77922-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2439058-23-6
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linker, and an E3 ligase recruiting ligand. This compound effectively induces HDAC6 degradation, displays superior selectivity over other HDAC isoforms, and efficiently inhibits cell proliferation [1].
Smiles
O=C(NO)C1=CC=C(C=C1)CN(C(=O)NC=2C=CC=CC2)CCCCC=3N=NN(C3)CCOCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6
Molecular Formula
C40H45N9O9
Molecular Weight
795.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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