Antitumor agent-192

• Target :

  Autophagy

• Related Pathways :

  Autophagy

• Bioactivity :

  Antitumor agent-192 (Compound 2f) is a ?-carboline antitumor compound. It induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. The IC50 of Antitumor agent-192 against human tumor cell lines is below 5 ?M, and it significantly inhibits tumor growth and reduces tumor weight in xenograft mouse models of colorectal cancer.

• Smiles :

  CCN(CC)CCCNCC1=CC2=C(C(=N1)CNCCCN(CC)CC)N(C3=CC=CC=C32)CCCC4=CC=CC=C4

• Molecular Formula :

  C36H54N6

• Molecular Weight :

  570.854

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C