TUS-007

• Target :

  Others|||Kras|||Ras

• Related Pathways :

  Others|||MAPK

• Bioactivity :

  TUS-007, a modified CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) molecule originally derived from a proteasome inhibitor, scarcely affects proteasome activity. It is a potent, orally active degrader of KRAS G12D/V, effective in cell-free chemical knockdown of KRAS G12D/V. Furthermore, TUS-007 has been shown to suppress tumor growth [1].

• Smiles :

  CC[C@@H](C)[C@H](NC(=O)CCCCCCNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)C(=O)Nc1ccc2nc(Cc3c[nH]c4ccccc34)[nH]c2c1

• Molecular Formula :

  C44H54Cl2N8O5

• Molecular Weight :

  845.86

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2227029-18-5