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TUS-007

CAT: 0931-T74755-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74755-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2227029-18-5
Target
Others, Kras, Ras
Related Pathways
Others, MAPK
Bioactivity
TUS-007, a modified CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) molecule originally derived from a proteasome inhibitor, scarcely affects proteasome activity. It is a potent, orally active degrader of KRAS G12D/V, effective in cell-free chemical knockdown of KRAS G12D/V. Furthermore, TUS-007 has been shown to suppress tumor growth [1].
Smiles
CC[C@@H](C)[C@H](NC(=O)CCCCCCNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)C(=O)Nc1ccc2nc(Cc3c[nH]c4ccccc34)[nH]c2c1
Molecular Formula
C44H54Cl2N8O5
Molecular Weight
845.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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