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TAS2940 free base

CAT: 0931-T202527-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T202527-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2451398-65-3
Target
EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
TAS2940 is an irreversible pan-ERBB inhibitor with enhanced brain penetration, utilized for treating lung cancer brain metastases and glioblastomas with HER2/EGFR exon 20 insertions and EGFR abnormalities. In intracranial xenograft models of HER2/EGFR cancers, TAS2940 has demonstrated efficacy in improving survival rates in mice. Currently, TAS2940 is undergoing Phase I clinical trials to establish the maximum tolerated dose for solid tumors.
Smiles
C(#CC1CC1)C=2N(C=3C(C2C(N[C@H](C)C4=CC=CC=C4)=O)=C(N)N=CN3)[C@H]5CN(C(C=C)=O)[C@@H](C)C5
Molecular Formula
C28H30N6O2
Molecular Weight
482.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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