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JAK2-IN-11

CAT: 0931-T201601-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201601-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3057053-17-2
Target
JAK
Related Pathways
Angiogenesis, Stem Cells, Chromatin/Epigenetic, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ≤10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.
Smiles
O=C1N(C=2C(N1C([2H])([2H])[2H])=CN=C(NC3=NC4=C(C(C(=O)N5CCC(C#N)CC5)=C3)C=CC=C4C(F)(F)F)C2)[C@H]6C[C@H](NC(OC)=O)CC6
Molecular Formula
C31H31F3N8O4
Molecular Weight
639.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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