JAK2-IN-11

• Target:

  JAK

• Related Pathways:

  Angiogenesis|||Stem Cells|||Chromatin/Epigenetic|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors

• Bioactivity:

  JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with potent antitumor activity, exhibiting an IC50 of ?10 nM against JH2 BIND WT/V617F. This compound effectively suppresses tumor growth.

• Smiles:

  O=C1N (C=2C (N1C ([2H]) ([2H]) [2H]) =CN=C (NC3=NC4=C (C (C (=O) N5CCC (C#N) CC5) =C3) C=CC=C4C (F) (F) F) C2) [C@H]6C[C@H] (NC (OC) =O) CC6

• Molecular Formula:

  C31H31F3N8O4

• Molecular Weight:

  639.64

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3057053-17-2