JAK3-IN-11

CAT: 0931-MF-0139394-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0139394-01Size:25 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2412734-00-8
Target
JAK|||Others
Related Pathways
Chromatin/Epigenetic|||Stem Cells|||Tyrosine Kinase/Adaptors|||Others|||Angiogenesis|||JAK/STAT signaling
Bioactivity
JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently binds to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T-cell proliferation which is a promising tool for studying autoimmune diseases [1].
Smiles
N(C=1N=C(C=CN1)C2=CC=C(NC(C=C)=O)C=C2)C3=CC=C(C=C3)N4CCOCC4
Molecular Formula
C23H23N5O2
Molecular Weight
401.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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