JAK2-IN-6

• Target :

  JAK

• Related Pathways :

  Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Stem Cells|||JAK/STAT signaling

• Purity :

  0.9964

• Bioactivity :

  JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 ?g/mL) . Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells.

• Smiles :

  Nc1nc(Nc2ccccc2)sc1C(=O)c1ccc(Cl)s1

• Molecular Formula :

  C14H10ClN3OS2

• Molecular Weight :

  335.83

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  353512-04-6