JAK2-IN-6

• Target:

  JAK

• Related Pathways:

  Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Stem Cells|||JAK/STAT signaling

• Purity:

  0.9964

• Bioactivity:

  JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 ?g/mL) . Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a variety of diseases, including some types of cancer and inflammatory diseases. JAK2-IN-6 has antiproliferative activity against cancer cells.

• Smiles:

  Nc1nc (Nc2ccccc2) sc1C (=O) c1ccc (Cl) s1

• Molecular Formula:

  C14H10ClN3OS2

• Molecular Weight:

  335.83

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  353512-04-6