RegisterLogin

JAK2-IN-7

CAT: 0931-T35900-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T35900-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
2593402-36-7
Target
JAK|||FLT|||Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||Stem Cells|||JAK/STAT signaling|||Angiogenesis|||Apoptosis
Purity
0.9954
Bioactivity
JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and selectivity. This compound demonstrates more than 14-fold selectivity against JAK1, JAK3, and FLT3, underlining its specificity. JAK2-IN-7 effectively induces cell cycle arrest at the G0/G1 phase and promotes apoptosis in tumor cells, manifesting significant antitumor activities [1].
Smiles
C(/C=C/CN(C)C)(=O)N1CC=2C(=CC(NC=3N=C(C(C)=CN3)C4=CN(C(C)C)N=C4)=CC2)CC1
Molecular Formula
C26H33N7O
Molecular Weight
459.59
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T62317-01α7 nAchR-JAK2-STAT3 agonist 1
T201601-01JAK2-IN-11
T88297-01JAK2-IN-10
T211933-01JAK2-IN-13
T71193-01Jak2-IN-7j
T210955-01JAK2-IN-12
T40443-01JAK2-IN-6
T11708-01JAK2-IN-4
T3042-01JAK2 Inhibitor V
T72754-01JAK2/STAT3-IN-1

Alternative Products

CatalogName
MBS3616634-01JAK2-IN-7
MBS3606718-01JAK2 inhibitor G5-7
HY-146066-01α7 nAchR-JAK2-STAT3 agonist 1
MBS8533783-01JAK2

Popular Products