JAK2-IN-13

• Target:

  STAT|||JAK

• Related Pathways:

  Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||JAK/STAT signaling|||Angiogenesis

• Bioactivity:

  JAK2-IN-13 is a potent and orally active JAK2 inhibitor with an IC50 of 54.7 nM. It downregulates the expression of p-STAT3 and p-STAT5 and exhibits good bioavailability. JAK2-IN-13 effectively suppresses recombinant human erythropoietin-induced extramedullary erythropoiesis as well as polycythemia vera. It is used in the study of myeloproliferative neoplasms.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C