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PPARδ agonist 11

CAT: 0931-T200543-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200543-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2982696-04-6
Target
PPAR
Related Pathways
DNA Damage/DNA Repair, Metabolism
Bioactivity
Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.
Smiles
O=C(O)COC1=CC=C(SCC2=NN=C(S2)C=3C=CC(=CC3)C(F)(F)F)C=C1C
Molecular Formula
C19H15F3N2O3S2
Molecular Weight
440.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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