PPAR? agonist 11

• Target:

  PPAR

• Related Pathways:

  DNA Damage/DNA Repair|||Metabolism

• Bioactivity:

  Compound 11, a selective PPAR? agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPAR? receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNF? and IL-6 in LPS-stimulated RAW264.7 cells via the NF-?B pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.

• Smiles:

  O=C(O)COC1=CC=C(SCC2=NN=C(S2)C=3C=CC(=CC3)C(F)(F)F)C=C1C

• Molecular Formula:

  C19H15F3N2O3S2

• Molecular Weight:

  440.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2982696-04-6