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PPAR agonist 7

CAT: 0804-HY-178958Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178958Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PPAR agonist 7 is an orally active pan-PPAR agonist, demonstrating potent activation of all three subtypes, PPARα (EC50 = 1.51 μM), PPARδ (EC50 = 1.11 μM), and PPARγ (EC50 = 3.14 μM). PPAR agonist 7 significantly enhances glucose uptake in adipocytes while exhibiting minimal adipogenic activity. PPAR agonist 7 can suppress PPARγ Ser273 phosphorylation in white adipose tissue and upregulate insulin-sensitizing genes. PPAR agonist 7 does not cause weight gain or fluid retention in high-fat diet (HFD) / Streptozotocin (STZ) -induced type 2 diabetes mellitus (T2DM) models. PPAR agonist 7 has selective modulation of PPAR signaling pathways without activation of adipogenic gene programs. PPAR agonist 7 can be used for the study of diabetes[1].
UNSPSC
12352005
Target
Adenosine Receptor; Endogenous Metabolite; Fatty Acid Synthase (FASN) ; PPAR
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology
Smiles
CC(C)(OC1=C(C)C=C(/C=C2OC3=CC(NCC4CC4)=CC=C3C\2=O)C=C1C)C(OC(C)(C)C)=O
Molecular Formula
C29H35NO5
Molecular Weight
477.59
References & Citations
[1]Bai S, et al. Design, synthesis and anti-diabetic evaluation of novel PPAR agonists based on functional group-oriented strategy. Eur J Med Chem. 2026 Jan 5;301:118226.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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