PPARα/γ agonist 3

• Description :

  PPARα/γ agonist 3 (Compound 4) is a dual agonist of PPARα/γ. PPARα/γ agonist 3 has anti-inflammatory activity, significantly reducing inflammatory markers such as IL-6 and MCP-1 on THP-1 macrophages through NF-κB activation. PPARα/γ agonist 3 can be used in the study of metabolic syndrome and metabolic dysfunction-related fatty liver disease (MAFLD) [1].

• UNSPSC :

  12352005

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pparα-γ-agonist-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C(COC2=CC(CCC(C)(CC/C=N/NC3=NC4=C(C=CC=C4)S3)O5)=C5C=C2)C=C1

• Molecular Formula :

  C27H26FN3O2S

• Molecular Weight :

  475.58

• References & Citations :

  [1]García A, et al. Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages[J]. European Journal of Medicinal Chemistry, 2024: 116125.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported