PPARα/γ agonist 3

• Description:

  PPARα/γ agonist 3 (Compound 4) is a dual agonist of PPARα/γ. PPARα/γ agonist 3 has anti-inflammatory activity, significantly reducing inflammatory markers such as IL-6 and MCP-1 on THP-1 macrophages through NF-κB activation. PPARα/γ agonist 3 can be used in the study of metabolic syndrome and metabolic dysfunction-related fatty liver disease (MAFLD) [1].

• UNSPSC:

  12352005

• Target:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pparα-γ-agonist-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=C(COC2=CC(CCC(C)(CC/C=N/NC3=NC4=C(C=CC=C4)S3)O5)=C5C=C2)C=C1

• Molecular Formula:

  C27H26FN3O2S

• Molecular Weight:

  475.58

• References & Citations:

  [1]García A, et al. Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages[J]. European Journal of Medicinal Chemistry, 2024: 116125.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported