PPARγ agonist 19

CAT: 0804-HY-176214Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176214Size:1 Each
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Description
PPARγ agonist 19 (Compound 5e) is a PPARγ agonist. PPARγ agonist 19 has an IC50 of 11.27 μM against COX-1 and an IC50 of 0.05 μM against COX-1. PPARγ agonist 19 increases glucose uptake in rat hemidiaphragm assay and is superior to pioglitazone (HY-13956) . PPARγ agonist 19 alleviates hyperglycemia and insulin resistance in an in vivo model of type 2 diabetes in rats and protects against renal and lipidemia damage caused by metabolic dysfunction[1].
UNSPSC
12352005
Target
COX; PPAR
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=S(C1=CC=C(N2N=NC(COC3=CC=C(/C=C(SC(N4)=S)/C4=O)C=C3OC)=C2)C=C1)(N)=O
Molecular Formula
C20H17N5O5S3
Molecular Weight
503.57
References & Citations
[1]Perihan A. Elzahhar, et al. Multi-Target Glitazones for Modulating Peroxisome Proliferator-Activated Receptor-γ, Cyclooxygenase-2, and Carbonic Anhydrases for the Management of Metabolic Dysfunction. ACS. Vol 8/Issue 6. 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2; PPARγ

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