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PPARα/δ agonist 3

CAT: 0804-HY-168485Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-168485Size:1 Each
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Description
PPARα/δ agonist 3 (Compound 8) is the orally active agonist for PPAR, that activates PPARα, PPARδ and PPARγ with EC50s of 5.6, 3.4 and 1278 nM, respectively. PPARα/δ agonist 3 exhibits anticholestatic activity in mouse ANIT- or CDCA (HY-76847) -induced cholestatic liver disease models[1].
CAS Number
[3050611-33-8]
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
CC(C)(OC1=C(C)C=C(CN2CCN(C3=CC=C(C(F)(F)F)C=C3)C2=O)C=C1C)C(O)=O
Molecular Formula
C23H25F3N2O4
Molecular Weight
450.45
References & Citations
[1]Fu Z, et al., Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases. Eur J Med Chem. 2025 Mar 15;286:117284.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ; PPARδ

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