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GPX4 24

CAT: 0931-T83780-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T83780-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others
Related Pathways
Others
Bioactivity
GPX4 24, a derivative of (1S,3R) -RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound effectively induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells with an EC50 value of 0.16 μM. Additionally, at a dose of 200 mg/kg, GPX4 24 elevates malondialdehyde (MDA) levels in both kidney and plasma of mice, highlighting its impact on lipid peroxidation.
Smiles
ClCC(N1[C@H](CC(C2=CC=CC=C2N3)=C3[C@@H]1C4=CC=C(C=C4)S(C)(=O)=O)C(OC)=O)=O
Molecular Formula
C22H21ClN2O5S
Molecular Weight
460.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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