GPX4 24

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  GPX4 24, a derivative of (1S,3R) -RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound effectively induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells with an EC50 value of 0.16 µM. Additionally, at a dose of 200 mg/kg, GPX4 24 elevates malondialdehyde (MDA) levels in both kidney and plasma of mice, highlighting its impact on lipid peroxidation.

• Smiles :

  ClCC(N1[C@H](CC(C2=CC=CC=C2N3)=C3[C@@H]1C4=CC=C(C=C4)S(C)(=O)=O)C(OC)=O)=O

• Molecular Formula :

  C22H21ClN2O5S

• Molecular Weight :

  460.93

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C