Products for Research Use Only

SI-2

CAT: 0498-bs-82720C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82720C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Si-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3) .1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3
Conjugation
Unconjugated
Buffer
Pale orange solid
Storage Conditions
-20°C