SI-2 (hydrochloride)

• UNSPSC Description:

  SI-2 (EPH 116 hydrochloride) is a highly promising SRC-3 inhibitor (PPI), with IC50 values of 3-20 nM for breast cancer cell death. SI-2 (EPH 116 hydrochloride) has a much improved toxicity and pharmacokinetic profile, with acceptable oral availability[1].

• Target Antigen:

  Estrogen Receptor/ERR; Others

• Type:

  Reference compound

• Related Pathways:

  Others;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/si-2-hydrochloride.html

• Purity:

  99.79

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  CN1C(N/N=C(C)/C2=CC=CC=N2)=NC3=CC=CC=C13.Cl

• Molecular Weight:

  301.77

• References & Citations:

  [1]Song X, et al. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1992052-49-9