2-APB

• Background:

  An IP3 receptor antagonist (IC50=42 μM) .1 Inhibits store-operated Ca2+ channels at high concentrations (50 μM) but stimulates at low concs. (<10 μM) .2 Modulates TRP channels, blocking TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8, TRPP2 and at higher concentrations, activating TRPV1, TRPV2, TRPV3.3,4 Also inhibits selected GAP junction subtypes.5

• Conjugation:

  Unconjugated

• Buffer:

  White solid

• Storage Conditions:

  -20°C