NHI-2

CAT: 0498-bs-82918C-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82918C-01Size:10 mg
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Background
NHI-2 is a selective inhibitor of Lactate Dehydrogenase A (LDHA) – IC50 in vitro = 14.7 µM (NADH), 10.5 µM (Pyruvate) .1 NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50 = 22.2 µM normoxic and 4.0 µM hypoxic; LPC006 cells IC50 = 17.8 µM normoxic and 1.1 µM hypoxic) with increased efficacy in a cancer cells hypoxic environment.2 LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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