(E/Z) -AG490

• Description:

  (E/Z) -AG490 ((E/Z) -Tyrphostin AG490) is a racemic compound of (E) -AG490 and (Z) -AG490 isomers. (E) -AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

• Product Name Alternative:

  (E/Z) -Tyrphostin AG490; (E/Z) -Tyrphostin B42

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  EGFR; JAK; STAT

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e-z-ag490.html

• Concentration:

  10mM

• Purity:

  99.71

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

• Molecular Formula:

  C17H14N2O3

• Molecular Weight:

  294.30

• Precautions:

  H302, H315, H319, H335

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [134036-52-5]