AG490

• Description:

  AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

• Product Name Alternative:

  Tyrphostin AG490; Tyrphostin B42

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H400

• Target:

  Autophagy; EGFR; JAK; STAT

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AG-490.html

• Purity:

  99.86

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

• Molecular Formula:

  C17H14N2O3

• Molecular Weight:

  294.30

• Precautions:

  H301, H400

• References & Citations:

  [1]Dowlati A, et al. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004 Apr;3 (4) :459-63|[2]Wang LH, et al. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation ofIL-2-mediated T cell response. J Immunol. 1999 Apr 1;162 (7) :3897-904.|[3]Davoodi-Semiromi A, et al. The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One. 2012;7 (5) :e36079.|[4]Cheppudira BP, et al. Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain. Biomed Rep. 2015 Sep;3 (5) :703-706.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EGFR/ErbB1/HER1; STAT3

• CAS Number:

  [133550-30-8]