AG490

CAT: 0400-SIH-428-5MGSize: 5 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-428-5MGSize:5 mg
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Background
AG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
Description
JAK-2 kinase inhibitor
CAS Number
133550-30-8
Product Name Alternative
Tyrphostin AG 490, N-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide, 2-Cyano-3- (3,4-dihydroxyphenyl) -N- (benzyl) -2-propenamide, 2-Cyano-3- (3,4-dihydroxyphenyl) -N- (phenylmethyl) -2-propenamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (TLC)
Weight
0.005
Format
Tan solid
Solubility
Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
Molecular Formula
C17H14N2O3
Molecular Weight
294.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Abe M., et al. (2009) Int. Immunopharma. 9(7-8): 870–877. 2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828. 3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.

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