CP-10

• Description :

  CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM) . It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  CDK; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cp-10.html

• Purity :

  98.41

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  CC(C(C1=O)=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)N=N5)CC4)C=N3)N=C2N1C9CCCC9)=O

• Molecular Formula :

  C44H49N13O7

• Molecular Weight :

  871.94

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CDK6; Cereblon

• CAS Number :

  [2366268-80-4]