CP-31398

• Description:

  CP-31398 can stabilize the active conformation of p53 and promote p53 activity in cancer cells with either mutant or wild-type p53. In addition, CP-31398 can upregulate p53 target genes, such as p21WAF1/Cip1 and KILLER/DR5. CP-31398 exerts an inhibitory effect on tumor growth[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Apoptosis; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cp-31398.html

• Smiles:

  CN (C) CCCNC1=C2C=CC=CC2=NC (/C=C/C3=CC=C (OC) C=C3) =N1

• Molecular Formula:

  C22H26N4O

• Molecular Weight:

  362.47

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286 (5449) :2507-10. |[2]Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1 (1) :47-55.|[3]J Wischhusen, et al. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene. 2003 Nov 13;22 (51) :8233-45.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  259199-65-0