CP-31398

CAT: 0804-HY-18343Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18343Size:1 Each
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Description
CP-31398 can stabilize the active conformation of p53 and promote p53 activity in cancer cells with either mutant or wild-type p53. In addition, CP-31398 can upregulate p53 target genes, such as p21WAF1/Cip1 and KILLER/DR5. CP-31398 exerts an inhibitory effect on tumor growth[1][2][3].
CAS Number
[259199-65-0]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp-31398.html
Smiles
CN(C)CCCNC1=C2C=CC=CC2=NC(/C=C/C3=CC=C(OC)C=C3)=N1
Molecular Formula
C22H26N4O
Molecular Weight
362.47
Precautions
P264-P270-P330-P501
References & Citations
[1]B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286 (5449) :2507-10. |[2]Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1 (1) :47-55.|[3]J Wischhusen, et al. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene. 2003 Nov 13;22 (51) :8233-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
BML-GR360-0010CP-31398
MBS387882-01CP 31398 2HCl
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MBS6044907-01CP-31398 Dihydrochloride
A15346-50CP 31398 dihydrochloride 50mg
A15346-100CP 31398 dihydrochloride 100mg
A13522-25CP 31398 2HCl 25mg
A15346-25CP 31398 dihydrochloride 25mg

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