CP-601932

CAT: 0804-HY-138879B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-138879B-01Size:5 mg
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Description
CP-601932 ((1S,5R) -CP-601927) is a high-affinity partial agonist at α3β4 nAChR (Ki=21 nM; EC50=~ 3 μM) . CP-601932 has the same high-binding affinity at α4β2 nAChR (Ki=21 nM) and an order of magnitude lower affinity for α6 and α7 nAChR subtypes. CP-601932 selectively decreases ethanol but not sucrose consumption and operant self-administration following long-term exposure. CP-601932 can penetrate the CNS[1].
CAS Number
[357425-68-4]
Product Name Alternative
(1S,5R) -CP-601927
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cp-601932.html
Purity
99.74
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
FC(F)(C1=CC=C([C@@H]2C[C@H]3CNC2)C3=C1)F
Molecular Formula
C12H12F3N
Molecular Weight
227.23
References & Citations
[1]Chatterjee S, et al. Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. Neuropsychopharmacology. 2011;36 (3) :603-615.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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