CP-609754

CAT: 0804-HY-16373-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16373-01Size:5 mg
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Description
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL[1]. CP-609754 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[1190094-64-4]
Product Name Alternative
LNK-754; OSI-754
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp-609754.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C)C2=C(C=C([C@](O)(C3=CC=C(Cl)C=C3)C4=CN=CN4C)C=C2)C(C5=CC=CC(C#C)=C5)=C1
Molecular Formula
C29H22ClN3O2
Molecular Weight
479.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10 (21) :7127-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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