CP-99994

• Description:

  CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Neurokinin Receptor; p38 MAPK

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  COC (C=CC=C1) =C1CN[C@@H]2[C@H] (C3=CC=CC=C3) NCCC2

• Molecular Formula:

  C19H24N2O

• Molecular Weight:

  296.41

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]McLean S, et al. Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor. J Pharmacol Exp Ther. 1993 Oct;267 (1) :472-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• Isoform:

  NK1R

• CAS Number:

  136982-36-0