Soluble CD14 Recombinant Protein

• Background:

  CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappa-β . CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space. Recombinant sCD14 is a 331 amino acid glycoprotein comprising the extracellular portion of the CD14 receptor.

• NCBI Gene ID:

  929

• Swiss Prot:

  P08571

• Accession Number:

  NP_000582.1

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Field of Research:

  Apoptosis, Immunology, Innate Immunity, Signal Transduction

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  The lyophilized Soluble CD14 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Soluble CD14 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Soluble CD14 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

• NCBI Official Name:

  CD14 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein

• Species:

  Human

• Protein ID:

  4557417

• Physical Properties:

  Lyophilized