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CD14 Recombinant Protein

CAT: 0223-96-108Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-96-108Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14) . Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa) . CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS) . CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP) . CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns. CD14+ cells are monocytes that can differentiate into a host of different cells. CD14 has been shown to interact with Lipopolysaccharide-binding protein.
CAS Number
9000-83-3
NCBI Gene ID
929
Swiss Prot
P08571
Accession Number
AAH10507
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Immunology, Innate Immunity, Signal Transduction
Purity
>98% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
36.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD14 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Kirkland TN, Viriyakosol S, et al., 1998, Prog. Clin. Biol. Res. 397: 79–87.
Background Reference 02
Kitchens RL., 2000, Chem. Immunol.. Chemical Immunology and Allergy 74: 61–82.
Background Reference 03
Tapping RI, Tobias PS., 2000, Chem. Immunol.. Chemical Immunology and Allergy 74: 108–21.
Background Reference 04
Thomas, Celestine J., et al., 2002, FEBS Lett. (Netherlands) 531 (2) : 184–8.
Other Product Names
CD14
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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