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CD14, soluble

CAT: 0209-100-406-L100Size: 100 µgDry Ice: NoHazardous: No
CAT#: 100-406-L100Size: 100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappaB. CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space. Recombinant sCD14 is a 331 amino acid glycoprotein comprising the extracellular portion of the CD14 receptor.
Synonyms
Soluble CD14
NCBI Gene ID
929
UniProt
P08571
Accession Number
NP_000582.1
Accession Number mRNA
NM_000591.3
Chromosomal Location
5q22-q32; 5q31.1
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
TTPEPCELDD EDFRCVCNFS EPQPDWSEAF QCVSAVEVEI HAGGLNLEPF LKRVDADADP RQYADTVKAL RVRRLTVGAA QVPAQLLVGA LRVLAYSRLK ELTLEDLKIT GTMPPLPLEA TGLALSSLRL RNVSWATGRS WLAELQQWLK PGLKVLSIAQ AHSPAFSCEQ VRAFPALTSL DLSDNPGLGE RGLMAALCPH KFPAIQNLAL RNTGMETPTG VCAALAAAGV QPHSLDLSHN SLRATVNPSA PRCMWSSALN SLNLSFAGLE QVPKGLPAKL RVLDLSCNRL NRAPQPDELP EVDNLTLDGN PFLVPGTALP HEGSMNSGVV P
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>95% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by the dose dependent activation of NF-kappaB in a RAW264 cell line based reporter system, using a sCD14 concentration range of 20 ng/μl to 200 ng/μl. The NF-kappaB activation is enhanced when the assay is done in the presence of 0.25 ng/μl to 1.0 ng/μl bacterial LPS.
Length
331
Form
Lyophilized
Molecular Weight
35.6 kDa
Host or Source
HEK293 cells

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