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CD14 Recombinant Protein

CAT: 0223-91-288Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0223-91-288Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD14 is a cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS binding protein (LBP) . Toll like receptors have also been implicated in the transduction of CD14-LPS signals. Soluble CD14 can be released from the cell surface by phosphatidyinositolspecific phospholipase C and has been detected in serum and body fluids. High concentrations of soluble CD14 have been shown to inhibit LPS mediated responses. However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.
CAS Number
9000-83-3
NCBI Gene ID
929
Swiss Prot
P08571
Accession Number
P08571
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Apoptosis, Immunology, Innate Immunity, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
36.81 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
CD14 molecule
NCBI Organism
Homo sapiens
Other Product Names
Monocyte Differentiation Antigen CD14, Myeloid Cell-Specific Leucine-Rich Glycoprotein, CD14
Species
Human
Physical Properties
Lyophilized

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