SuperKillerTRAIL, Soluble Recombinant Protein

• Background:

  TNF-related apoptosis-inducing ligand (TRAIL; Apo2L; CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B) . Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC) .

• NCBI Gene ID:

  22035

• Swiss Prot:

  P13236

• Accession Number:

  P50592

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  E. coli

• Field of Research:

  Other

• Concentration:

  0.5mg/ml

• Buffer:

  In 20mM HEPES, pH 7.4, 300mM NaCl, 0.01% Tween 20, 1% sucrose, 1mM DTT.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Once thawed it is recommended to prepare appropriate aliquots and to store them at -80˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  Tumor necrosis factor (ligand) superfamily, member 10

• NCBI Organism:

  Mus musculus

• Other Product Names:

  TRAIL, Apo-2L, TNFSF10, CD253

• Species:

  Human, Mouse

• Protein ID:

  1730016

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3