Twist2 Antibody

• Background:

  Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

• NCBI Gene ID:

  117581

• Swiss Prot:

  Q8WVJ9

• Accession Number:

  NP_476527.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Twist2 antibody was raised against a peptide sequence around aa.26~30 (P-K-R-F-G) derived from Human Twist2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  18 kDa

• Specificity:

  This antibody detects endogenous level of total Twist2 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  TWIST2

• NCBI Official Name:

  Twist family bHLH transcription factor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lee M. S., Lowe G., Flanagan S., Kuchler K., Glackin C. A. Bone 27:591-602 (2000)

• Other Product Names:

  FFDD3, DERMO1, SETLSS, bHLHa39, MGC117334

• Tested Applications:

  WB

• Protein ID:

  17981708

• Physical Properties:

  Liquid