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Twist1 Antibody

CAT: 0223-79-743Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-743Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
NCBI Gene ID
7291
Swiss Prot
Q15672
Accession Number
NP_000465.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Twist1 antibody was raised against a peptide sequence around aa.18~22 (S-N-S-E-E) derived from Human Twist1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
28 kDa
Specificity
This antibody detects endogenous levels of total Twist1 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
TWIST1
NCBI Official Name
Twist family bHLH transcription factor 1
NCBI Organism
Homo sapiens
Background Reference 01
"Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. "Sosic D., Richardson J. A., Yu K., Ornitz D. M., Olson E. N. Cell 112:169-180 (2003) "Mutations of the TWIST gene in the Saethre-Chotzen syndrome. "el Ghouzzi V., le Merrer M., Perrin-Schmitt F., et al., Nat. Genet. 15:42-46 (1997)
Other Product Names
CRS, SCS, ACS3, CRS1, BPES2, BPES3, TWIST, bHLHa38
Tested Applications
WB
Protein ID
4507741
Physical Properties
Liquid

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