TLE1 Antibody

• Background:

  Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

• NCBI Gene ID:

  7088

• Swiss Prot:

  Q04724

• Accession Number:

  Q04724

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TLE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the Central region of human TLE1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  83 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TLE1

• NCBI Official Name:

  Transducin-like enhancer protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ali, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (9) :4165-4169 (2010)

• Background Reference 02:

  Jagdis, A., et al. Am. J. Surg. Pathol. 33 (12) :1743-1751 (2009)

• Background Reference 03:

  Kosemehmetoglu, K., et al. Mod. Pathol. 22 (7) :872-878 (2009)

• Other Product Names:

  Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1

• Tested Applications:

  WB

• Protein ID:

  29840816

• Physical Properties:

  Liquid