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TLE1 Antibody

CAT: 0223-64-027Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-027Size:400 µL
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Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
NCBI Gene ID
7088
Swiss Prot
Q04724
Accession Number
Q04724
Host
Rabbit
Reactivity
Human
Immunogen
This TLE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the Central region of human TLE1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
83 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TLE1
NCBI Official Name
Transducin-like enhancer protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Ali, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (9) :4165-4169 (2010)
Background Reference 02
Jagdis, A., et al. Am. J. Surg. Pathol. 33 (12) :1743-1751 (2009)
Background Reference 03
Kosemehmetoglu, K., et al. Mod. Pathol. 22 (7) :872-878 (2009)
Other Product Names
Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1
Tested Applications
WB
Protein ID
29840816
Physical Properties
Liquid

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