TLE4 Antibody

• Background:

  TLE4 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) .

• NCBI Gene ID:

  7091

• Swiss Prot:

  Q04727

• Accession Number:

  Q04727

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TLE4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human TLE4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  84 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TLE4

• NCBI Official Name:

  Transducin-like enhancer protein 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, Y., et al. PLoS Genet. (11), E1000707 (2009) :

• Background Reference 02:

  Hancock, D.B., et al. PLoS Genet. (8), E1000623 (2009) :

• Background Reference 03:

  Stolk, L., et al. Nat. Genet. (2009) In press :

• Background Reference 04:

  Dayyani, F., et al. Blood 111 (8) :4338-4347 (2008)

• Other Product Names:

  Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261

• Tested Applications:

  WB

• Protein ID:

  158518541

• Physical Properties:

  Liquid