TLE2 Antibody

• Background :

  TLE2 belongs to the WD repeat Groucho/TLE family. It contains 6 WD repeats. TLE2 is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.

• NCBI Gene ID :

  7089

• Swiss Prot :

  Q04725

• Accession Number :

  NP_003251

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TLE2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  Antibody is purified by peptide affinity chromatography method.

• Positive Control :

  Tranfected 293T Cell Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TLE2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  80 kDa

• Applications Notes :

  TLE2 antibody can be used for detection of TLE2 by ELISA at 1:312500. TLE2 antibody can be used for detection of TLE2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  TLE2

• NCBI Official Name :

  Transducin-like enhancer of split 2 (E (sp1) homolog, Drosophila)

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Higa, L.A., (2006) Nat. Cell Biol. 8 (11), 1277-1283.

• Other Product Names :

  TLE2, ESG, ESG2, FLJ41188, GRG2

• Tested Applications :

  ELISA, WB

• Protein ID :

  21361151

• Physical Properties :

  Liquid