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PI3KCG Antibody

CAT: 0223-63-450Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-450Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PIK3CG belongs to the pi3/pi4-kinase family of proteins. It is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene for this protein is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
NCBI Gene ID
5294
Swiss Prot
P48736
Accession Number
P48736
Host
Rabbit
Reactivity
Human
Immunogen
This PI3KCG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-547 amino acids from the Central region of human PI3KCG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
126 kDa
Fragment
Rabbit Ig
Symbol
PIK3CG
NCBI Official Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
NCBI Organism
Homo sapiens
Background Reference 01
Andreozzi, F., et al., Endocrinology 145 (6) :2845-2857 (2004) .
Background Reference 02
Reddy, S.A., et al., Biochem. Biophys. Res. Commun. 316 (4) :1022-1028 (2004) .
Background Reference 03
Osaki, M., et al., J. Cancer Res. Clin. Oncol. 130 (1) :8-14 (2004) .
Background Reference 04
Khan, N.A., et al., J. Neurovirol. 9 (6) :584-593 (2003) .
Other Product Names
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, PI3-kinase subunit gamma, PI3K-gamma, PI3Kgamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p110gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K, PIK3CG
Tested Applications
WB, IHC-P
Protein ID
92090623
Physical Properties
Liquid

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