PI3KCD Antibody

• Background:

  Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

• NCBI Gene ID:

  5293

• Swiss Prot:

  O00329

• Accession Number:

  O00329

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PI3KCD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 687-717 amino acids from the C-terminal region of human PI3KCD.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  119 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PIK3CD

• NCBI Official Name:

  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vanhaesebroeck, B., et al., Proc. Natl. Acad. Sci. U.S.A. 94 (9) :4330-4335 (1997) .

• Background Reference 02:

  Chantry, D., et al., J. Biol. Chem. 272 (31) :19236-19241 (1997) .

• Other Product Names:

  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, PI3-kinase subunit delta, PI3K-delta, PI3Kdelta, PtdIns-3-kinase subunit delta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, PtdIns-3-kinase subunit p110-delta, p110delta, PIK3CD

• Tested Applications:

  WB, IHC-P, IF

• Physical Properties:

  Liquid