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PI3KCB Antibody

CAT: 0223-63-344Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-344Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
NCBI Gene ID
5291
Swiss Prot
P42338
Accession Number
P42338
Host
Rabbit
Reactivity
Human
Immunogen
This PI3KCB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713-744 amino acids from the C-terminal region of human PI3KCB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
123 kDa
Fragment
Rabbit Ig
Symbol
PIK3CB
NCBI Official Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
NCBI Organism
Homo sapiens
Background Reference 01
Brock, C., et al., J. Cell Biol. 160 (1) :89-99 (2003) .
Background Reference 02
Kossila, M., et al., Diabetes Care 26 (1) :179-182 (2003) .
Background Reference 03
Yart, A., et al., J. Biol. Chem. 277 (24) :21167-21178 (2002) .
Background Reference 04
Ueki, K., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (1) :419-424 (2002) .
Other Product Names
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, PtdIns-3-kinase subunit beta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, PtdIns-3-kinase subunit p110-beta, p110beta, PIK3CB, PIK3C1
Tested Applications
WB, IHC-P
Protein ID
1171955
Physical Properties
Liquid

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