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PI3KCA Antibody

CAT: 0223-63-342Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-342Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. This protein represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns (4,5) P2. PI3KCA has been found to be oncogenic and has been implicated in cervical cancers.
NCBI Gene ID
5290
Swiss Prot
P42336
Accession Number
P42336
Host
Rabbit
Reactivity
Human
Immunogen
This PI3KCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1019-1050 amino acids from the C-terminal region of human PI3KCA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
124 kDa
Fragment
Rabbit Ig
Symbol
PIK3CA
NCBI Official Name
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
NCBI Organism
Homo sapiens
Background Reference 01
Tiwari, S. Nat Immunol. August; 10 (8) : 907?17 (2009) .
Background Reference 02
Ballou, L.M., et al., J. Biol. Chem. 278 (26) :23472-23479 (2003) .
Background Reference 03
Singh, B., et al., Genes Dev. 16 (8) :984-993 (2002) .
Background Reference 04
Shayesteh, L., et al., Nat. Genet. 21 (1) :99-102 (1999) .
Other Product Names
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA, PIK3CA
Tested Applications
WB, IHC-P, Flow
Protein ID
126302584
Physical Properties
Liquid

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