YWHAZ Antibody

• Background:

  YWHAZ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

• NCBI Gene ID:

  7534

• Swiss Prot:

  P63104

• Accession Number:

  P63104

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This YWHAZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from human YWHAZ.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  YWHAZ

• NCBI Official Name:

  14-3-3 protein zeta/delta

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Powell, D.W., et al., Mol. Cell. Biol. 23 (15) :5376-5387 (2003) .

• Background Reference 02:

  Zhu, P., et al., Biochem. Biophys. Res. Commun. 301 (4) :991-999 (2003) .

• Background Reference 03:

  Li, Y., et al., J. Biol. Chem. 277 (47) :44593-44596 (2002) .

• Background Reference 04:

  Wang, H., et al., J. Clin. Endocrinol. Metab. 87 (6) :2629-2634 (2002) .

• Other Product Names:

  14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1, YWHAZ

• Tested Applications:

  WB, IHC-P

• Protein ID:

  52000887

• Physical Properties:

  Liquid