MAP4K1 Antibody

• Background:

  MAP4K1 or HPKI (hematopoietic progenitor kinase I) is one of these mammalian kinases that have significant sequence similarity to the Saccharomyces Cerevisiae serine/threonine kinase STE20, which relays signals from G protein coupled receptors to cytosolic MAP kinase cascades. MAP4K1 may play a role in the response to environmental stress. It appears to act upstream of the JUN N terminal pathway. It may play a role in hematopoietic lineage decisions and growth regulation.

• NCBI Gene ID:

  11184

• Swiss Prot:

  Q92918

• Accession Number:

  Q92918

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAP4K1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from human MAP4K1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  91 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MAP4K1

• NCBI Official Name:

  Mitogen-activated protein kinase kinase kinase kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hu M.C.-T., Genes Dev. 10:2251-2264 (1996) .

• Background Reference 02:

  Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135 (2004) .

• Background Reference 03:

  Wissing J., Mol. Cell. Proteomics 6:537-547 (2007) .

• Other Product Names:

  Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1

• Tested Applications:

  WB

• Protein ID:

  29427916

• Physical Properties:

  Liquid